Nifedipine has been used in concentrations
of 0.2% to 10% PLO gel in an effort to enhance circulation
in areas of ischemia. Pharmacists use higher concentrations,
but the lower doses are a better starting point due
to the hypotensive properties of this drug. The same
vasodilatation properties that make it work well orally
in diseases such as hypertension, angina pectoris, and
Raynaud’s syndrome could also make it work well
as an agent to rub on areas around diabetic ulcers and
in ischemic areas to aid in blood flow. The patient
should be monitored for decreased blood pressure while
using the preparation, and the wound should be monitored
for signs of healing (skin becoming more pink, vascularized
and skin dryness) around the wound.
- Nifedipine 4-16% transdermal
- Pentoxifylline 5% Lipoderm
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