There are numerous medications that are commercially available to treat diabetic neuropathy and help return sensitization. Some of the drugs used to treat diabetic neuropathy are amitriptyline, baclofen, ketamine, gabapentin, and clonidine. Diabetic patients can benefit from topical combinations of these medications that are not commercially available. Combinations of topical medications have the advantage of fewer adverse effects as well as using one medication rather than several.

Possible formulas:

• Amitriptyline 2%/ Baclofen 2% transdermal
• Baclofen 5%/Ketoprofen 10%/Lidocaine 5%/Gabapentin 5% transdermal
• Ketamine 10%/Gabapentin 6%/Clonidine 0.2%/Lidocaine 2% transdermal
• Ketamine 10%/Gabapentin 6%/Clonidine 0.2%/Nifedipine 2% transdermal
• Gabapentin 6%/Clonidine 0.2% transdermal
• Clonidine 0.2%/Gabapentin 6%/Ketamine 10% transdermal